Topic of Study: Inflammatory Bowel Disease This is a multicenter, prospective randomized controlled trial in which adults with IBD are randomized to four IBD self-help interventions to determine the impact of the interventions on patients' physical and psychosocial function and self-efficacy.

Topic of Study: Breast Cancer This is a Phase III, randomized, open-label, multicenter study evaluating the efficacy and safety of Giredestrant plus Everolimus compared with the physician's choice of endocrine therapy plus Everolimus in patients with estrogen receptor-positive, HER2-negative, locally advanced or metastatic breast cancer. (Clinicaltrials.gov ID#: NCT05306340)

Topic of Study: Inflammatory Bowel Disease This is a 6-month, multicenter prospective trial to assess the feasibility and effectiveness of a remote monitoring digital health system on adherence, clinical outcomes, and healthcare utilization for patients with Crohn's Disease or Ulcerative Colitis who are beginning treatment with either IV or subcutaneous vedolizumab.

Topic of Study: Inflammatory Bowel Disease This is a pragmatic, open-label, multicenter randomized controlled trial conducted in asymptomatic patients with IBD who have persistent moderate to severe endoscopic inflammation despite optimization of index targeted immunomodulatory (TIM). This clinical trial aims to collect and analyze data in patients with IBD who are currently receiving IBD medication(s) that targets their immune system (TIM) in routine clinical care, and to determine if switching to an alternative IBD medications will improve their disease outcome without increasing the burden of their treatment. (Clinicaltrials.gov ID# NCT05230173)

Topic of Study: Inflammatory Bowel Disease This is a phase III, multicenter, double-blind, placebo-controlled, treat-through study. The goals of this clinical trial are to evaluate the efficacy and safety of RO7790121 compared with placebo in inducing and maintaining remission in patients with moderately to severely active Crohn's Disease and Ulcerative colitis.

Topic of Study: Inflammatory Bowel Disease The goals of this study are to create a prospective cohort of well phenotyped adult IBD patients with serial clinical and patient reported data and biosamples collected throughout the course of their disease. This data will be used to identify predictors of response to IBD therapies and of disease relapse.

Topic of Study: Breast Cancer This is a Phase 3 open-label, randomised study of Datopotamab Deruxtecan (Dato-DXd) with or without Durvalumab versus investigator’s choice of therapy in patients with Stage I-III Triple-negative breast cancer who have residual invasive disease in the breast and/or axillary lymph nodes at surgical resection following Neoadjuvant Systemic Therapy. (Clinicaltrials.gov ID#: NCT05629585)