Topic of Study: Appendiceal Cancer The primary aim of the study is to determine the microbiological environment of the peritoneal tissues of patients undergoing cytoreductive surgery with intraoperative hyperthermic chemotherapy for appendix cancer with peritoneal spread.

Topic of Study: Breast Biopsy, Colorectal Cancer, Solid Tumors The Biorepository for Caris Life Sciences is designed for the purpose of making quality biospecimens and associated clinical data available for research studies related to advancing precision medicine and improving care for patients. (Clinicaltrials.gov ID#: NCT01499394)

Topic of Study: Gastrointestinal Disease This study is a phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of cenicriviroc for the treatment of liver fibrosis in adult subjects with nonalcoholic steatohepatitis. (AURORA)

Topic of Study: Appendiceal Cancer

This study is a phase II, open label, historical controlled study to determine the impact of antibiotic therapy on the disease progression and overall survival of the patients with Pseudomyxoma Peritonei (PMP). The study will examine the use of the antibiotic PREVPAC, in patients undergoing CRS/HIPEC for appendiceal neoplasms with peritoneal dissemination and its effect on patient outcomes and survival. (ClinicalTrials.gov ID#: NCT02387203)

Topic of Study: Appendiceal Cancer The primary aim of the study is to determine whether the gastrointestinal microbiome of appendiceal cancer patients with peritoneal spread differs from a healthy, age-matched cohort of the American population. This is a collaborative study with the University of California, San Diego and Rob Knight, PhD who will perform the genetic analysis of bio-specimens from patients who undergo cytoreductive surgery with HIPEC. (Clinical Trials ID #: NCT02599116)

Topic of Study: Breast Cancer

This study is designed for patients desiring nipple reconstruction following surgery for breast cancer and breast reconstruction. Eligible patients will receive a surgical procedure to reconstruct one or both nipples utilizing the COOK® Biodesign® Plastic Surgery Matrix. The study is designed to evaluate the benefit of this device in achieving effective and aesthetic nipple reconstruction. Patients will be evaluated at the time of the procedure and at 1 week, 4 weeks, 3 months, 6 months, and 12 months after surgery to examine the projection of their reconstructed nipple(s) and patient satisfaction (Cook Medical Study 09-009; Clinicaltrials.gov ID#: NCT01216319).

Topic of Study: Breast Cancer This is a Phase III, Double-blind, Randomized study to assess switching to AZD9833 (a Next Generation, Oral SERD) plus a CDK4/6 Inhibitor (Palbociclib or Abemaciclib) versus continuing an Aromatase Inhibitor (Letrozole or Anastrozole) plus CDK4/6 Inhibitor in patients with Hormone receptor positive (HR+), HER2 negative metastatic breast cancer with a detectable ESR1 Mutation without disease progression during first line treatment. - A ctDNA Guided Early Switch Study (Clinicaltrials.gov ID#: NCT04964934) 

Topic of Study: Breast Cancer This study is a randomized, double-blind, phase 3 study of tucatinib or placebo in combination with trastuzumab and pertuzumab as maintenance therapy for first line, metastatic HER+2 breast cancer (Clinicaltrials.gov ID#: NCT05132582).  

Topic of Study: Other This study involves storing specimens from CRS/HIPEC patients with advanced colorectal, gastric, small bowel, primary peritoneal, ovarian cancers, peritoneal mesothelioma, and sarcomas. The purpose is to collect, maintain, and store tissues specimens from CRS/HIPEC and clinical data for future research. The collection of clinical data and outcomes from CRS/HIPEC for advanced intra-abdominal cancers will be used to refine future treatment protocols and enhance patient care

Mercy primary care physician Dr. Shannarose Guma discusses essentials you should have for you and your family.