Topic of Study: Breast Cancer This is a Phase III, randomized, open-label, multicenter study evaluating the efficacy and safety of Giredestrant plus Everolimus compared with the physician's choice of endocrine therapy plus Everolimus in patients with estrogen receptor-positive, HER2-negative, locally advanced or metastatic breast cancer. (Clinicaltrials.gov ID#: NCT05306340)

Topic of Study: Inflammatory Bowel Disease The goals of this study are to create a prospective cohort of well phenotyped adult IBD patients with serial clinical and patient reported data and biosamples collected throughout the course of their disease. This data will be used to identify predictors of response to IBD therapies and of disease relapse.

Topic of Study: COVID-19 Infection Join a study to help us find ways to prevent and treat the long-term health effects of COVID, called Long COVID. Researchers will compare people who had COVID to people who have never had COVID - this helps us learn things that may be related to Long COVID, such as certain symptoms or health conditions. You can join if you've had COVID in the past 30 days. This study will not give anyone a treatment or medicine for COVID. If you join this study, you can still take treatments and medicines your doctor gives you.

Topic of Study: Breast Cancer This is a Phase Ib/III, open-label, randomised study of Capivasertib plus CDK4/6 inhibitors and Fulvestrant versus CDK4/6 inhibitors and Fulvestrant in Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative locally advanced, unresectable or metastatic breast cancer. (Clinicaltrials.gov ID#: NCT04862663)

Topic of Study: Appendiceal Cancer This is a study to define the pathological staging for appendiceal neoplasms by examining mutations of the genetic makeup of tumor tissue and to analyze prognostic factors associated with various stages of appendiceal cancer with peritoneal dissemination.

Topic of Study: Breast Cancer This study is designed to optimize endocrine therapy through motivational interviewing and text interventions. It will evaluate endocrine therapy adherence in women exposed to text message reminders only, telephone-based motivational interviewing counseling only, or both, versus usual care. (Clinicaltrials.gov ID#: NCT04379570)

Topic of Study: Inflammatory Bowel Disease This is a 6-month, multicenter prospective trial to assess the feasibility and effectiveness of a remote monitoring digital health system on adherence, clinical outcomes, and healthcare utilization for patients with Crohn's Disease or Ulcerative Colitis who are beginning treatment with either IV or subcutaneous vedolizumab.